Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor
نویسندگان
چکیده
Nobutaka Shimizu,* Kimiko Yamamoto,* Syotaro Obi, Shinichiro Kumagaya, Tomomi Masumura, Yasumasa Shimano, Keiji Naruse, Jun K. Yamashita, Takashi Igarashi, and Joji Ando Department of Biomedical Engineering and Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan; Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan; Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
منابع مشابه
Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta.
Embryonic stem (ES) cells are exposed to fluid-mechanical forces, such as cyclic strain and shear stress, during the process of embryonic development but much remains to be elucidated concerning the role of fluid-mechanical forces in ES cell differentiation. Here, we show that cyclic strain induces vascular smooth muscle cell (VSMC) differentiation in murine ES cells. Flk-1-positive (Flk-1+) ES...
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تاریخ انتشار 2008